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New FRAP-3D Enables Multidimensional Photobleaching & Photoactivation Studies

Tucson, AZ — MAG Biosystems™ is pleased to introduce FRAP-3D™, the world’s first widefield imaging system designed specifically to study the intracellular dynamics of proteins and other macromolecular complexes via high-speed, multidimensional FRAP (fluorescence recovery after photobleaching) and iFRAP (inverse FRAP) experiments. Photoactivation and photoconversion studies with fluorescent proteins such as PA-GFP, EOS, KFP, Kaede, and Dronpa can also be performed. 

Several unique innovations, including Live FRAP w/ Instant Recall™, Burst mode, and a custom optical path, provide a combination of speed, sensitivity, and ease of use not found in any other FRAP system. Live FRAP w/ Instant Recall allows researchers to acquire a complete FRAP experiment via a single click of the mouse while viewing their sample in real-time. Burst mode captures the first post-bleach image less than 25 msec from the end of the last bleach pulse, enabling the study of rapidly diffusing macromolecules. Custom optics combine laser illumination with widefield illumination in a single beampath, permitting simultaneous FRAP and widefield illumination. This lets researchers perform standard widefield imaging experiments without making mechanical changes to the system. 

FRAP-3D includes a galvanometer-based FRAP head, an innovative laser launch module with integrated I/O circuitry to control all aspects of the system, the world’s first and only quantitatively stable 16-bit EMCCD camera (the QuantEM™), acquisition and analysis software, and a configured workstation. The system’s FRAP head mounts easily to many popular inverted microscopes through the epi-illumination port. 

MAG Biosystems — a Photometrics systems brand

MAG Biosystems products are designed, manufactured, marketed, and supported by the Microimaging Applications Group™, which comprises imaging leaders Photometrics®, Gatan®, Media Cybernetics®, and QImaging®. These technology partners work independently as well as in synergy to offer an unparalleled range of solutions for microimaging applications.